Closer to "Sneak, hide, and be very, very quiet." I want there to be a heavier emphasis on realism and survival, meaning guns and ammunition are not only rare, but also dangerous, in that the sound of gunfire would attract further Infected to the area. Also, the appearance of Infected would only be controlled by myself and those who have a character who became infected during the coarse of the roleplay that were able to turn into an Infected. Again, to add further emphasis on survival by removing the factor of being able to control when the Infected appear.
As far as plot, I picture it taking several weeks after the initial infection, originating in Las Vegas and spreading out from there. Apart from the typical "find a safe haven" cliche, I was thinking the party could also go in search for a mysterious military base code-named "Jericho." Whether that base be the ultimate safe haven, the answer to all the questions about the outbreak, or something else entirely is up for debate.
Also, considering the Pentagon now officially has a plan and protocol in case of a "zombie apocalypse" (which is a lot less comforting than if they didn't), I thought the inclusion of this military base is suddenly a lot more realistic.
Granted, this is all open to change, depending on the general consensus toward it.