The best spot at the time for me was at the Henne Mines from the trail that leads you to the RNG Zodiac Spear treasure.
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There's missable items like with every other JRPG, although they're mostly useless and will only sit there in your inventory for the sake of having them. You can lock yourself out of additional licenses based on which Quickening licenses you use to get your 3 Quickenings and of course, where you allocate your Espers.
But no missable trophies, and no superboss will become impossible just because you don't pick the optimal job combinations if that's what you are worried about.
I've got the game. I already fucked up so I'm restarting from Reks.
I kinda wish we could have just stuck with Reks the whole game and never switched to Vaan haha.
I think Basch was the original, and intended main playable character for the game.
I actually like Vaan. We get many of the best character interactions thanks to him. His scenes with Ashe are all great.
But yeah, originally Basch was supposed to be the lead but the higher ups wanted a younger poster boy for the game. That being said, this happened fairly early on during the development. Vaan wasn't a last minute addition like some people seem to think. At the end of the day it's an ensemble cast, but if anyone of them fills the role of a protagonist it's Ashe.
I get that, I get the being dragged into it or along for the ride type of deal. But I think it's a little more strange when said characters, or at least Vaan, is technically our protagonist. Our kind of lead dude is just along for the ride. Although, I guess it's got a kind of poetic Gatsby feel to it in that sense.
Again, I don't hate Vaan, I don't want it to seem like I hate Vaan. And I do agree that he has some great character interactions, like he fits in with the cast well, just the way he meshes into the larger story... Not so much. It seemed to me like he pushed through without much actual reason other than... I don't know, adventure(?) for a large portion of the game before any reason actually came up for him to need to be there.