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DRAG-ON DRAGOON 3
Genre: RPG/Action RPG
Platform: PS3
Developer: Access Games
Publisher: Square Enix
http://www.jp.square-enix.com/dod3/
Main characters are supposedly "Zero" and "One", who I think were in this Drag-On Dragoon manga, though I believe they just share names only.
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Zero and One are sisters. Zero uses the power of "Utautai" to manipulate magic. Flowers grow from her right eye. One is a serious-natured character, and very intelligent.
I think this is the UE3 game, but I'm not sure.